MIT-Ivy Kev Lag Luam yog kev lag luam tshuaj thiab tshuaj lom neeg nruab nrab kev lag luam sib koom ua ke ntawm kev tsim khoom, muag thiab kev tshawb fawb tshawb fawb.With cov cuab yeej tsim khoom thiab cov cuab yeej siv ntau lawm, peb muaj kev sib raug zoo nrog kev sib raug zoo nrog cov tsev kawm tshawb fawb thiab cov tsev kawm ntawv loj thiab nruab nrab.Peb tsuas yog koom nrog kev tsim khoom thiab muag khoom ntawm cov tshuaj intermediates series, tshwj xeeb tshaj yog nyob rau hauv kev kho mob ntawm anti-AIDS, mob plawv thiab cerebrovascular tshuaj, thiab txhawb intermediates ntawm anti-inflammatory tshuaj.Cov khoom ntawm sodium azide, triphenyl chloromethane, L- valine methyl ester hydrochloride yog muag hauv tsev thiab txawv teb chaws.1.Kev taw qhia ntawm cov kws tshuaj intermediates Pharmaceutical intermediates xa mus rau cov khoom nruab nrab xws li cov khoom siv raw, cov khoom siv thiab cov excipients siv los tsim cov khoom siv tshuaj.Qhov tseeb, lawv yog qee cov tshuaj raw khoom lossis cov khoom siv tshuaj hauv cov txheej txheem ntawm cov tshuaj synthesis.The pictureManufacturers of proprietary tshuaj. thiab cov tshuaj nquag yuav tsum tau txais GMP ntawv pov thawj.Pharmaceutical intermediates, txawm tias siv hauv kev tsim tshuaj, yog qhov tseem ceeb tsuas yog kev sib txuas thiab tsim cov khoom siv tshuaj lom neeg.Lawv yog cov khoom siv yooj yim tshaj plaws thiab hauv qab hauv cov khoom siv tshuaj thiab tsis tuaj yeem hu ua cov tshuaj, yog li tsis tas yuav muaj ntawv pov thawj GMP. Cov tshuaj intermediates tuaj yeem tsim hauv cov nroj tsuag tshuaj zoo tib yam thiab tuaj yeem siv rau hauv kev sib xyaw ntawm cov khoom siv tshuaj ntawm qee qib. kuj txo qhov nkag nkag ntawm kev lag luam rau nruab nrab manufacturers.Cov duab2.Scale of pharmaceutical intermediates kev lag luam Nrog kev hloov kho ntawm cov qauv kev lag luam, kev hloov pauv ntau lawm thiab kev ua kom zoo ntxiv ntawm kev faib thoob ntiaj teb ntawm kev ua haujlwm ntawm cov tuam txhab lag luam loj multinational, Tuam Tshoj tau dhau los ua ib qho tseem ceeb hauv nruab nrab ntau lawm hauv ntiaj teb kev faib ua haujlwm ntawm kev lag luam kws tshuaj. Daim ntawv tshaj tawm txog Kev Txhim Kho ntawm Tuam Tshoj Pharmaceutical Intermediates Kev Lag Luam (2016), los ntawm 2011 txog 2015, Tuam Tshoj tus kws tshuaj intermediates kev lag luam thiab nws tag nrho cov txiaj ntsig tau nce xyoo los ntawm lub xyoo, nrog rau kev loj hlob txhua xyoo ntawm kwv yees li 13.5%. Cov tshuaj intermediates nyob rau hauv Tuam Tshoj mus txog 422.56 billion yuan nyob rau hauv 2015, nce ntawm 9.88% xyoo nyob rau hauv lub xyoo.Industry tso zis mus txog 17.2 lab tons, nce 10.26 feem pua ​​​​nyob rau hauv lub xyoo.Tus nqi tso zis ntawm kws tshuaj intermediates kev lag luam nyob rau hauv Tuam Tshoj yuav ze rau ib trillion. yuan los ntawm 2020.Cov duab 3.Muaj cov yam ntxwv ntawm cov kws tshuaj intermediatesCov kev lag luam yog qhov xav tau kev kho kom zoo thiab kho dua tshiab: Tuam Tshoj tus txheej txheem thev naus laus zis tag nrho tseem tsis tshua muaj, thiab muaj ob peb lub lag luam tsim cov khoom lag luam loj heev thiab txhawb cov intermediates rau cov tshuaj tshiab patented, uas yog nyob rau hauv txoj kev loj hlob. theem ntawm cov khoom tsim optimization thiab upgrading.Tsuas yog ib co tuam txhab uas muag muaj zog kev tshawb fawb thiab kev loj hlob lub zog, advanced ntau lawm chaw thiab loj-scale ntau lawm kev yuav tau txais high profits nyob rau hauv kev sib tw.Stable lag luam scale: loj-scale manufacturers yeej coj customized ntau lawm raws li lawv lub ntsiab. ua lag luam qauv.Raws li tus qauv tsim kho, kev sib koom tes ntawm cov neeg siv khoom loj thiab cov neeg muag khoom yog qhov ruaj khov, thiab kev sib raug zoo ntawm kev sib raug zoo, kev ntseeg siab dua, thiab ntau pawg kev koom tes muab los ntawm cov neeg siv khoom loj yuav siv sij hawm ntev los hloov. cov neeg muab khoom.Yog li ntawd, raws li ib tug lag luam nrog muaj zog stickiness, tshuaj intermediates kev lag luam tuam txhab uas muag feem ntau tsom mus rau lub zoo-paub txawv teb chaws kws tshuaj tuam txhab uas muag nyob rau hauv lub tam sim no theem.Thaum lub tuam txhab nkag mus rau hauv lub core tsum system ntawm kws giants, ob qho tag nrho cov scale thiab cov nyiaj tau los tag nrho tuav ib tug. Lub xeev ruaj khov.Low-end export tsuas yog: lub ntsiab export cheeb tsam ntawm kws tshuaj intermediates nyob rau hauv Tuam Tshoj yog EU, North America, Middle East, Southeast Asia, thiab lwm yam.Lub export ntawm peb lub teb chaws mas concentrated nyob rau hauv vitamin C, penicillin, acetaminophen, citric acid thiab nws cov ntsev thiab esters, xws li cov khoom lag luam, cov yam ntxwv ntawm cov khoom yog cov khoom tsim, kev lag luam ntau lawm, kev sib tw ua lag luam yog khaus, cov khoom lag luam thiab tus nqi ntxiv yog tsawg, qhov loj ntawm lawv ua rau cov khoom lag luam nruab nrab ntawm cov khoom lag luam oversupply. Cov khoom siv thev naus laus zis tseem tseem yog imported.Me thiab nruab nrab cov lag luam: cov khoom lag luam enterprIses feem ntau yog cov lag luam ntiag tug, kev ua haujlwm yooj yim, kev nqis peev tsis loj, feem ntau ntawm ntau lab mus rau kaum lossis nees nkaum lab yuan.Regional concentration: lub regional faib ntawm cov tuam txhab tsim khoom yog cov concentrated, nyob ib ncig ntawm ob peb lub tuam txhab tshuaj loj, feem ntau faib hauv Taizhou, Zhejiang. thiab Jintan, Jiangsu raws li qhov chaw nruab nrab ntawm cheeb tsam.Zhejiang Huangyan, Taizhou, Nanjing Jintan, Shijiazhuang, Jinan (xws li Zibo), sab qaum teb sab hnub tuaj (Siping, Fushun) thiab lwm thaj chaw uas muaj kev pom zoo rau kev loj hlob ntawm cov kws tshuaj intermediates tau tsim tshwj xeeb sai heev. Cov khoom lag luam hloov tshiab sai: cov khoom lag luam feem ntau yog nyob rau hauv kev ua lag luam 3 mus rau 5 xyoo tom qab, nws cov nyiaj tau los yuav poob qis, uas ua rau cov tuam txhab tsim khoom tshiab los yog niaj hnub txhim kho cov txheej txheem ntau lawm, txhawm rau kom muaj txiaj ntsig ntau lawm.Intensive kev sib tw. : vim tias cov nyiaj tau los ntawm cov tshuaj intermediates yog siab dua li of cov khoom siv tshuaj, thiab cov txheej txheem tsim khoom ntawm ob lub hauv paus yog tib yam, ntau thiab ntau cov tuam txhab tshuaj me me koom nrog kev tsim cov tshuaj intermediates, ua rau muaj kev sib tw tsis sib haum xeeb hauv kev lag luam.4.Cov tshuaj intermediates muaj ntau hom tshuaj intermediates, xws li cephalosporin intermediates, amino acid tiv thaiv series, vitamin intermediates, quinolone intermediates, thiab lwm yam intermediates, xws li tshuaj tua kab mob intermediates, antiepileptic tshuaj intermediates, fluoropyridine intermediates, intermediates steroid thiab lwm yam. .Raws li lawv daim ntawv thov teb, lawv tuaj yeem muab faib ua cov tshuaj tua kab mob intermediates, antipyretic thiab analgesic tshuaj intermediates, cardiovascular system tshuaj intermediates, anti-cancer tshuaj intermediates thiab lwm yam.Tam sim no, muaj txog pua pua ntawm cov tshuaj intermediates khoom, thiab tas li. innovate, tsim ntau nplua molecular industries nyob rau hauv cov kws tshuaj intermediates kev lag luam.Muaj ntau ntau hom kev tshuaj intermediates.Xws li imidazole, furan, phenolic intermediates, aromatic intermediates, pyrrole, pyridine, biochemical reagents, sulfur, nitrogen, halogen compounds, heterocyclic compounds, microcrystalline cellulose, starch, mannitol, lactose, dextrin, ethylene glycol, hmoov qab zib, inorganic ntsev, ethanol intermediates, stearic acid, amino acid thiab ethanol amine ntsev, sylvite, sodium ntsev thiab lwm yam intermediates. Daim duab 5.Patent CliffSince 2000, lub ntiaj teb no generics lag luam tau nce zuj zus sai dua li tag nrho cov khw muag tshuaj, loj hlob ntau tshaj ob zaug sai li patented tshuaj.Lub ntiaj teb no generic tshuaj lag luam yuav tsum mus txog $180 billion nyob rau hauv 2013, thiab CAGR ntawm lub ntiaj teb no generic. Kev lag luam tshuaj los ntawm 2005 txog 2013 yuav tsum ncav cuag 14.7%. Lub ntiaj teb no generics lag luam yuav tsum loj hlob los ntawm 10% mus rau 14% nyob rau hauv tsib lub xyoos tom ntej no, sai npaum li qhov kev cia siab 4% mus rau 6% kev loj hlob rau tag nrho cov kws lag luam. Nws tuaj yeem pom tau tias kev txhim kho ntawm kev lag luam tshuaj lag luam yuav pom tseeb txhim kho kev lag luam tshuaj nruab nrab.Los ntawm 2010 txog 2020, lub khw muag tshuaj thoob ntiaj teb yuav ua rau muaj kev kub ntxhov ntawm Patent tas sij hawm, ntawm cov uas, txij xyoo 2013 txog 2020, lub ntiaj teb no Patent tas sij hawm ntau yam yuav nruab nrab ntau tshaj 200 txhua xyoo, uas yog hu ua "Patent Cliff" nyob rau hauv lub ntiaj teb no.In 2014, yuav muaj ib tug ncov ntawm patent tshuaj tas sij hawm, nyob rau hauv uas yuav muaj ib tug p.eak hauv 2014, nrog tag nrho ntawm 326 patent tshuaj tas sijhawm.2010 thiab 2017 yog ob lub xyoo txheeb ze, nrog 205 thiab 242 cov tshuaj patent tas sijhawm.Cov tshuaj tas sij hawm yog cov tshuaj tiv thaiv kab mob, endocrine, paj hlwb thiab cov hlab plawv cov tshuaj, nrog rau kev lag luam loj loj.Qhov loj-scale tas sij hawm ntawm txawv teb chaws patented tshuaj yuav coj cov catalysts tshiab rau cov kws tshuaj intermediates kev lag luam hauv Suav teb.Vim tias tom qab tas sij hawm ntawm patent. tshuaj, kev tsim cov tshuaj muaj feem xyuam nrog cov tshuaj yuav tawg, uas yuav ua rau muaj kev loj hlob sai ntawm qhov kev thov rau cov tshuaj intermediates.Cov duab 6.Environmental pressureChina twb yog ib tug loj exporter ntawm API intermediates, raws li zoo raws li ib tug loj polluter.Pharmaceutical intermediate manufacturers koom nyob rau hauv zoo tshuaj kev lag luam, yuav muaj ib tug coj pollution txaus ntshai.Raws li kev txheeb cais los ntawm Ministry of Environmental Protection, tag nrho cov nqi tso zis ntawm lub Kev lag luam kws tshuaj hauv tsev yog tsawg dua 3 feem pua ​​​​ntawm lub teb chaws GDP, tab sis tag nrho cov pa phem emissions ncav cuag 6 feem pua. Ntawm txhua yam tshuaj, API feem ntau sawv cev los ntawm cov vitamins thiab penicillin belongs rau kev lag luam muaj kuab paug thiab siv zog siab, uas ua phem rau huab cua thiab dej tshwj xeeb heev.Raws li kev sib koom ua ke ntawm Ministry of Environmental Protection, thaum Lub Ob Hlis 15, 2017, pab pawg tshuaj xyuas tshwj xeeb rau huab cua zoo hauv thawj peb lub hlis twg xyoo 2017 tau tshaj tawm tias kev ua haujlwm siab hauv Shijiazhuang tsis yog. nyob rau hauv qhov chaw, thiab lub county-level tsoom fwv tseem yog feem ntau raws li Environmental Kev Tiv Thaiv Cov Neeg Ua Haujlwm hauv kev ua raws li cov phiaj xwm hnyav huab cua thaum muaj xwm txheej ceev, thaum lwm lub tuam tsev tsis koom nrog kev kawm siab.Cov pa phem ntawm cov lag luam me thiab nruab nrab uas tsim cov tshuaj intermediates hauv Shijiazhuang yog qhov hnyav. Cov lag luam tshuaj nrog cov cuab yeej rov qab yuav dais Kev tswj cov pa phem siab thiab kev tswj xyuas siab, thiab cov chaw lag luam tshuaj niaj hnub feem ntau tsim cov pa phem, kev siv hluav taws xob siab thiab cov khoom muaj nqis ntxiv (xws li penicillin, vitamins, thiab lwm yam) yuav ntsib kev tshem tawm sai.Adhering rau cov txheej txheem innovation thiab tsim ntsuab tshuaj technology. tau dhau los ua kev txhim kho yav tom ntej ntawm kws tshuaj intermediates kev lag luam.Cov duab
7. Cov thawj coj hauv kev lag luam
mit-ivy kev lag luam
Zhejiang NHU Co., Ltd
Lianhe Chemical Technology Co., Ltd. Anhui Bayi Tshuaj Co., Ltd Zhejiang Huahai Pharmaceutical Co., Ltd. Zhejiang Hisoar Pharmaceutical Co., Ltd.Jiangsu Jiujiu Technology Co., Ltd Tsoom fwv teb chaws kws tshuaj (chengdu) co., LTDZhejiang Yongtai Technology Co., Ltd. Specialty Chemical Co., Ltd.