N,N-bis(2-chloroethyl)carbamate tert-butyl ester siv tau ua ib qho nruab nrab hauv kev tshuaj lom neeg thiab kev tsim cov organic. Hauv kev hloov pauv organic synthesis, pawg Boc hauv cov qauv tuaj yeem tshem tawm yooj yim kom tau txais pawg carboxyl nquag.

Txoj kev tsim ua ke no suav nrog kev sib xyaw sai ntawm bis-(2-chloroethyl)amine hydrochloride (5 g, 0.028 mol) hauv dichloromethane (42 mL) nrog rau10% sodium hydroxide aqueous solution (28 mL) ntawm qhov kub thiab txias ntawm lub dab dej khov. Ib qho tshuaj ntawm di-tert-butyl dicarbonate (6.11 g, 0.028 mol) hauv dichloromethane (28 mChemicalbook L) ces ntxiv rau. Tom qab do ntawm chav sov li 18.5 teev, dichloromethane (30 mL) maj mam ntxiv rau hauv cov tshuaj sib tov. Ob theem ces sib cais. Cov theem dej ntxiv raug rho tawm nrog dichloromethane (30 mL). Cov txheej organic sib xyaw ua ke raug ziab hla anhydrous magnesium sulfate, lim, thiab ua kom muaj N,N-bis(2-chloroethyl)carbamate tert-butyl.